📚 Volume 25, Issue 9
📋 ID: xlKLbIw
Authors
Lamia Mabrouki, Anouar Ben Saad, Jihen Taleb, Sana Ncib and Lazhar Zourgui
Higher Institute of Applied Biology ISBAM Medenine 4119, University of Gabes, Tunisia and Research of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112, University of Gafsa, Tunisia
Abstract
In the present study, the anti-obesity and hepatoprotrctive effect of the aqueous extract of Moringa oleifera leaves (AEMOL) was investigated using a high fat diet (HFD) induced obese rabbits. AEMOL was subjected to different phytochemical analyses including total phenolic and flavonoid content phenolic compounds and vitamin E profiles were identified by mean of high-performance liquid chromatography (HPLC-DAD). Anti-obesity and hepatoprotective effect of AEMOLwere tested in plasma and liver tissue after chronic administration of HFD in rabbits. Supplementation of obese rabbits with AEMOL resulted in a significant change in body weight, triglycerides, total cholesterol, and LDL level as compared to the HFD-induced obesity. Further AEMOL normalized liver biomarkers, elevated hepatic antioxidant defense capacities by increasing the activities of catalase (CAT), superoxide-dismutase (SOD), and glutathione-peroxidase (GPx), and prevented damage in the hepatic histoarchitecture. The therapeutic potential of AEMOL could be attributed to its richness in bioactive and antioxidant compounds.
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📝 How to Cite
Lamia Mabrouki, Anouar Ben Saad, Jihen Taleb, Sana Ncib and Lazhar Zourgui (2018).
"Moringa oleifera leaves: Phytochemical composition and evidence for an anti-obesity and hepatoprotective intervention in high-fat-diet-induced obese rabbits".
Wulfenia, 25(9).
