Abstract\nThis study was applied to investigate the hepatoprotective activity of ethanolic extracts of edible Guava (Pisidium guajava) and Olive (Olea uropaeal L.) alone and against carbon tetrachloride (CCl4) induced hepatic damage in rats. Oral administration of CCl4 (1 ml/kg body wt. /day S/C) induced a chronic hepatotoxicity resulting elevated serum level of glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP). The substantially elevated serum marker enzyme levels were restored towards normalization by the extracts treatment when administered at a dose of 500 mg/kg body wt. once daily for one month. The hepatic antioxidant status such as catalase (CAT), glutathione peroxidase (GPX), glutathione S. transferase (GST) and total antioxidant activity (TAC) levels are reduced in CCl4 alone treated animals with subsequent increase in malondaldhyde lipid peroxidase (MDA). Administration of the extracts challenge restored the hepatic antioxidant status. Furthermore, histopathological studies confirmed the hepatoprotective effect. The findings suggested that ethanolic extracts of Guava (Pisidium guajava) and Olive (Olea uropaeal L.) exhibited a high liver protection against CCl4 induced chronic hepatotoxicity in rats by restoring the liver antioxidant status.\nKeywords: Antioxidant, Guava, Pisidium guajav, Olive, Olea uropaeal L. Carbon tetrachloride, Hepatoprotective effect.

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