Objectives: To evaluate the coincidence of Helicobacter pylori (H. pylori) infection in patients presenting with varied otorhinolaryngological diseases.\nPatients & Methods: The study included 292 patients; 173 males and 119 females with mean age of 25.9±15.4 years. All patients underwent complete otorhinolaryngological evaluation, urea breath test (UBT) using the Heliprobe 14C UBT and the obtained surgical specimens or effusion samples or swabs were examined by polymerase chain reaction (PCR) for detection of H. pylori DNA.\nResults: According to results of UBT, 41 patients were infected, 107 patients had borderline infection and 144 patients were free of infection. PCR examination of H. pylori DNA detected 62 positive cases with a true positive rate of 80.5% for positive and 27.1% for borderline UBT. PCR assured H. pylori infection in 5 patients had CRS with polyposis, in 9 patients with CRS without polyposis, in 17 patients and in 10 patients with pharyngitis without tonsillitis. PCR confirmed H. pylori infection in 15 patients with chronic otitis media (COM) with effusion and in 6 patients with laryngitis.\nConclusion: Upper air passages could be considered as reservoir for H. pylori that must be considered as an underlying pathogenic mechanism for various otorhinolaryngological disorders and must be excluded prior to surgical decision making. Urea breath test must be applied as a routine test at otorhinolaryngological clinics.

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