Phoenix dactylifera L. is a medicinal plant and it is extensively used in prevention and cure for chronic diseases. The present study investigated the effect of antidepressant, analgesic, anti-inflammatory and anticoagulant activities in rats by P. dactylifera extracts. Methanolic extracts of P. dactylifera fruit extract (PDF), P. dactylifera seed extract (PDS) and P. dactylifera fruit and seed extract mixture (PDM) for antidepressant, analgesic, anti-inflammatory and anticoagulant activities in Sprague Dawley rats at 300, 200 and 100mg/kg body weight. Results indicated that TST and FST showed that rats struggling efforts and immobility time were higher in PDS, while locomotory behavior and immobility time were significantly increased in PDS and PDM, respectively. All extracts showed good antidepressant activity, but the highest value was exhibited by PDS, whereas analgesic activity and reduction in edema were demonstrated by PDF. Moreover, PDM revealed prominent anticoagulant activity and moderate activity in PDF. We can conclude that Phoenix dactylifera extracts prolongs the clotting time and have the potential to reduce the platelet aggregations, depression and inflammation. Further studies needed to find out the active components responsible for pharmacological effects.

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