antioxidant activities antimicrobial activities purified sulforaphane Brassica oleracea var. rubra

Sulforaphane (SFN), an isothiocyanate found in red cabbage, possesses anticancer, antioxidant, and antimicrobial activities. The objective of the study was to examine the antioxidant activity of purified SFN in terms of 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging, as well as the levels of Glutathione S-Transferase (GST) and reduced glutathione (GSH) in Vero and HEp-2 cells. The results indicated that the extract possesses higher radical scavenging activity in HEp-2 and Vero cells compared to purified SFN. Purified and standard SFN were found to have similar radical scavenging activities in these cells. GST and GSH levels in SFN-treated Vero and HEp-2 cells were decreased compared to control cells. The antimicrobial activity of purified SFN was assessed using the diffusion method, revealing good antimicrobial activity against various bacterial and fungal species. The study suggests that purified SFN and its extract can exert antioxidant stress by scavenging free radicals and controlling xenobiotic metabolism in Vero and HEp-2 cells.

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