Garcinia hombroniana has been used in Malay traditional medicine to treat various disorders such as abdominal pain and gonorrhea, and little is known about its toxicological properties. This study investigated the acute toxicological effects of the plant’s leaves aqueous extract using the oral acute toxic class (ATC) method. Twenty-four female Sprague-Dawley rats were divided into control, T1, T2 and T3 groups. The T1, T2, and T3 rats administered a single oral dose of 300, 2000 and 5000 mg/kg of body weight of G. hombroniana leaves aqueous extract, respectively. The animals were observed daily for abnormal clinical signs and death for 14 days. Body weight, relative organ weight, daily feed and water consumption, hematological and biochemical parameters of blood as well as heart, kidney, liver and spleen tissues histology were evaluated. Results have shown significant (p<0.05) decrease in feed and water consumption in T2 and T3 rats, which returned to normal after 72 hours post administration. No significant differences (p≥0.05) in the hematological and serum biochemical parameters in the treated rat groups, compared to the untreated control animals, were observed. An increase in the relative weight of spleen was observed in T3 animals. Congestion of the splenic, hepatic, cardiac and renal tissues was observed in T2 and T3 rats. The oral LD50 was higher than 5000 mg/kg of body weight and, hence, it can be concluded that G. hombroniana aqueous extract shows little toxicity in the laboratory rats and is a good candidate for further investigation of its therapeutic potentials.

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