The disposition kinetic of florfenicol either alone or concurrently with flunixin meglumine was studied following single intravenous and intramuscular injections in dairy goats. Five clinically healthy lactating goats were injected with florfenicol in a dose of 20 mg kg-1b.wt. intravenously and intramuscularly with one month period in between. The same protocol was repeated after one month but flunixin (2.5 mg kg-1b.wt.) was concurrently administered with florfenicol. Samples of blood for serum, and samples of urine, milk and ruminal juice were taken from each goat at specific time intervals. Florfenicol concentrations were determined in all samples using HPLC. Following i.v injection of florfenicol and flunixin, there was a significant increase in Cpᴼ, k12, k21 and a significant decrease in MRT, t0.5α, Vdss, Vc, Vdarea and VdB of florfenicol compared to florfenicol when administered alone. After intramuscular injection, there was a significant increase in Kab, Cmax, AUC, MRT and F % and a significant decrease in Tmax and t0.5ab values of florfenicol following injection of florfenicol with flunixin. Moreover, flunixin meglumine alters the protein binding tendency of florfenicol and affect its rate of excretion in urine, milk and ruminal juice. Significant variation in the disposition of florfenicol when concurrently administered with florfenicol was reported and should be considered when the two drugs are used concurrently.

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