Natural product compounds havea nitrogen or oxygen heterocycles such as polyphenolic compounds and alkaloids are broad in nature and therapeutic plants, specifically, have end up being a wellspring of practically limitless N-determined construction .This study aims to study the effect of natural heterocyclic compounds constittents of the leaves of Eruca sativa as anticancer and antioxidant agents. Also, an eco-friendly synthesizes copper and pladium nanoparticles using E. sativa leaves’s aqueous extract and to evaluate antioxidant and cytotoxic activities of both CuONPs and PdNPs and compare with aqaus extract of E. sativa. Nanoparticles produced were elucidated by UV– Vis spectroscopy, FT-IR, XRD, and HR-TEM analysis. Then, the purified nanoparticles for both copper and palladium as spherical red pellets were then investigated for antioxidant assay using DPPH method. In addition, to assess the Cytotoxic effect of the CuNPs & PdNPs on Human Colon carcinoma (HCT-116), Human Lung carcinoma (A549) and the normal human liver fibroblast cell line (WISH) was assessed by MTT assay. The study observed the IC50 value of PdNPs has most potent cytotoxic activity on different cell lines against as 14.4 ±0.2 µg/ml,18.3 ± 1.9 µg/ml and 43.1± 3.14 µg/ml for HCT-116, A549 and WISH cell lines respectively .

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