The aim of the study was to investigate the vitamin D level in normotensive and hypertensive patients with diabetes mellitus type 2 (T2DM) with/without cardiovascular disease (CVD). Cross-sectional data of 155 patients with T2DM were analyzed. Sixty-seven patients had CVD (aged 63.6±1.0yrs, BMI 29.2±0.5kg/m2). Eighty-eight diabetic patients did not have the history of CVD (aged 61.0±0.9yrs, BMI 29.9±0.4kg/m2). We compared these two groups of patients with T2DM with 87 healthy subjects (35 male/52 female, aged 52.8±1.4yrs, BMI 27.2±0.5kg/m2). Weight, height, waist circumference, body mass index (BMI), blood pressure and history of antihypertensive drugs were recorded in all subjects. Total cholesterol, triglycerides, HbA1c and 25(OH)D levels were measured in all subjects. According to 25(OH)D level, we divided all subjects into three categories: severe vitamin D deficiency (≤15ng/ml), vitamin D insufficiency (15-20ng/ml) and vitamin D sufficiency (˃20ng/ml). Normotensive and hypertensive patients with T2DM without CVD were vitamin D sufficient in comparison with healthy subjects (21.8±1.2ng/ml and 21.6±1.1ng/ml vs. 22.6±0.8ng/ml,p˃0.05). Hypertensive patients with T2DM with CVD (n=49) were vitamin D insufficient in comparison with healthy subjects (19.4±0.9ng/ml vs. 22.6±0.8ng/ml; p=0.017; Z-2.397). This cross-sectional study showed that there were no differences in vitamin D levels between normotensive and hypertensive patients with T2DM.

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