Extracts of aqueous ethanol 70% (ETOH-E), hot water (AQ-E), and a partially purified extract by liquid-liquid extraction with ethyl acetate (ETAC-E) were obtained of the stem bark of two Mangifera indica L. varieties: Manila y Tommy Atkins. Total phenolics, total flavonoids, antioxidant activity by DPPH•, ABTS•, FRAP assays, the cytotoxic effect on the growth of MCF-7 cell cultures were evaluated. A chromatographic comparison by HPLC, and the identification of the main phenolic compounds by UV spectra and Mass Spectra were investigated. The (ETAC-E) possess highest antioxidant activity, while (ETOH-E) showed cytotoxic effect on MCF-7 cell cultures growth. Both species shown high chromatographic similarity in phenolic compounds profile, the main compound present is mangiferin. The results suggesting that the extracts of both species could be used for nutraceutical purposes and have cytotoxic effect on the growth of MCF-7 cell cultures, which suggests a potential application for cancer treatments.

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