The objective of this work was to conduct a brief review of updated literature, addressing the use of intravascular laser irradiation of blood (ILIB), in a transcutaneous way. ILIB is a technique that uses low intensity laser light, applied over a blood vessel, with the aid of a directing bracelet for the light beam, in order to reach the circulating blood cells. It consists of a therapeutic modality capable of providing photobiomodulation, with modulation of inflammation, vasodilation, stimulation of cellular metabolism and the immune system, stabilization of hormonal levels and improvement of microcirculation systemically. Its effectiveness is due to its ability to activate the antioxidant system, with activation of the superoxide dismutase enzyme (SOD), in addition to stimulating prostacyclin as well. However, further clinical studies with consolidated protocols and results are still needed for this technique to be applied based on scientific evidence.

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