📚 Volume 25, Issue 4 📋 ID: 8zOSDTx

Authors

Kurtanov Kh.A, Pavlova N.I., Sydykova L.A., Fillipova N.P., Solovjeva N.A., Neustroeva L.M., Diakonova A.T., Varlamova M.A., Dodohov V.V., Ivanova O.N., Borisova N.V., Stepanov K.M.

1Federal State Budgetary Scientific Institution “Yakut Science Center of Complex Medical Problems”

Abstract

Our research goal is to carry out the analysis ofdiversity of the FTO gene and the relation of gene variants with obesity at Yakuts with type 2 diabetes mellitus. 132 DNA samples from patients with the diagnosis of diabetes mellitus type 2 were tested (women - 91, men - 41). In the cohort of a healthy comparison group, there was created a sampling of 22 men and 48 women. Distribution analysis of allelic and genotypes frequencies of polymorphic variant of the FTO gene (rs9939609) in the group of patients with type 2 diabetes mellitus and the healthy comparison group did not diagnosticate significant differences. In both groups prevailed the T allele (р=0.252) and the TT homozygous genotype (р=0.820); an exception was the group of apparently healthy men which, in despite of the T allele prevalence (р=0.08), was characterized by the highest level of AT heterozygous genotype (Ho=0.546). It was found that a marker of the higher risk of obesity development of Yakut patients with type 2 diabetes mellitus on ethnic origin are the TT homozygous genotype of FTO gene (rs9939609).
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📝 How to Cite

Kurtanov Kh.A, Pavlova N.I., Sydykova L.A., Fillipova N.P., Solovjeva N.A., Neustroeva L.M., Diakonova A.T., Varlamova M.A., Dodohov V.V., Ivanova O.N., Borisova N.V., Stepanov K.M. (2018). "THE STUDY OF THE FTO GENE IN YAKUT POPULATION SUFFERING FROM TYPE 2 DIABETES MELLITUS". Wulfenia, 25(4).