Objective: Verify the effect of Tinospora cordifolia extract for reducing the effects of alcohol on the specific enzymes in chronic alcoholics. Method: A systematic review of quasi-experimental clinical studies. The primary study sources used were the Cochrane Library, Embase, Latin American and Caribbean Health Sciences (LILACS), PubMed (including MedLine), SciELO, and Web of Science electronic databases. The statistical analysis was performed with the Mantel-Haenszel method with 95% confidence interval and I-square test. The accumulation of evidence was performed using the GRADE tool. Results: The search provided 1673 results, from which five met the inclusion criteria. The studies were published between 2015 and 2016 in India and assessed the effects of Tinospora cordifolia for improving hepatic biomarkers. The studies included presented low risk of bias. The results of the meta-analysis showed that there was a statistically significant difference in the parameters evaluated in the experimental group and the control group, with better results for the control group in both D0 (p <0.001) and D14 (p <0.001). Conclusion: The results suggest that the use of Tinospora cordifolia helped improving the hepatic levels assessed. However, it was not sufficient to generate reductions in levels of biomarkers similar to those in the control group.

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