The oxazolophenazine 2 was prepared by cyclocondensation of compound 1 and aceticanhydride. The synthesis of oxazolophenazine (3a-d) was acheived by the oxidative addittion of phenazine 1 with aromatic aldhyde. The addition of compound 1 to the activated acrolene furinsed the oxazine derivative 4. Alkylation followed by cyclization of compound 1 using phenacyl bromide and/or ethyl acetochloroacetate yielded oxazine cylization affording 5 and 6 respectively. The cyclocondensation of compound 1 with cyanoacetamide afforded pyrrolophenazine 7. The oxazine 8 was genarated by alkylation of compound 1 in pyridine followed by cyclization. Antifungal activity was screened for three compounds 6, 7 and 8 with two fungal species Candida albicans and Aspergillus niger. The three tested compounds 6, 7 and 8 had different antifungal activities against the two tested fungal strains.

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