Introduction: Morinda citrifolia Linn (Noni), is known for its anti-tumor, antimicrobial, antioxidant, and anti-inflammatory benefits, in addition to being an important ally for weight loss, possibly acting as an appetite suppressant. Due to the lack of study and possibly being related to cases of hepatitis, the commercialization of the fruit was banned by ANVISA, however, it continued its dissemination in the media as a potent agent in the fight against obesity. Objective: To evaluate liver function, blood glucose, and cholesterol levels of obese Wistar females using Morinda citrifolia Linn (Noni). Methods: The project was submitted to the approval and approval of the Ethics Committee on the Use of Animals (CEUA) of Faculdade Ceres, São José does Rio Preto-SP, under protocol number 008/2016. There were 14 Wistar rats divided into 2 groups of 7 animals being called the control group (C), which received water, and Noni group (N), which received 30% Noni juice, both for 90 days. The hyperlipidemic diet was prepared to contain 20% of lipid content, counting with the percentage of total fat existing in the commercialized diet. For each 1,500g of cooked rice, 200g of commercialized feed, 300g of lard, and 100 mL of water were added. After mixing, 100g portions were prepared. The treatment was started when the animals were over 450g. The Noni juice was prepared with ripe fruits, with a whitish-yellow aspect, after washing in running water, they were beaten in a centrifuge to obtain the pure pulp. For every 90 g of savings, 300 ml of water was added. Three blood samples were taken from the animals, one before treatment, 45 and 90 days. The TGP, TGO, and total cholesterol measurements were performed by spectrophotometry with commercial kits. After sacrificing for high doses of analgesics, the liver was removed for later staining with hematoxylin and eosin. Statistical analyzes were performed using the T-test and Fisher\'s exact test. Results: Group N had an average weight gain of 90.86g (SD +/- 89.089g) at the end of 90 days, while Group C the average was 126.29g (SD +/- 69.991g) with a difference between statistically significant groups (p=0.047). Group C had a mean TGO value of 23.15 mg/dL (SD +/- 5.488570) and group N of 15.90 mg / dL with p = 0.028, while TGP the mean was 5.1857 mg / dL (SD +/- 1.7667mg/dL) and 5.6714 (SD +/- 3.4630) (p = 0.747) respectively. When comparing the cholesterol values of groups C and N with 45 days of treatment were 78.60 mg / dL (SD +/- 21.925) and 74.59 (SD +/- 14.43) (p = 0.693); for 90 days 89.97 mg/dL (SD +/- 4.563) and 50.96 mg/dL (SD +/- 8.344) (p<0.001) respectively. When comparing the blood glucose values of groups C and N with 45 days of treatment, they were 63.33 mg/dL (SD +/- 18.206) and 68.97 mg/dL (SD +/- 22.989); for 90 days of treatment 155.36 mg/dL (SD +/- 18.316) and 76.34 mg/dL (SD +/- 7.155) respectively. Steatosis was the histological alteration present in both groups, however, when severity was classified, group N presented 100% of moderate and severe cases, while group C showed a difference between groups with p=0.001. Conclusion: Noni in a concentration of 30% for 90 days had an action related to the animals\' weight loss, presented a hypoglycemic and hypocholesterolemic action. Despite the hypocholesterolemic function, it worsened liver steatosis, reduced TGO values , and did not change TGP values.

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