ABSTRACT\n\n\nMethanol extract was prepared from Alhagi maurorum and evaluated for its potential antiulcerogenic and hepatoprotective effects in rats. Preliminary phytochemical analysis and acute LD50 were also carried out. Oral administration of the methanol extract (400 and 800 mg kg-1) of Alhagi maurorum significantly (P<0.05) decreased the average ulcer index in a dose dependent manner with a curative ratio of 69.6 and 74.6% for the small and large dose respectively, in the ethanol-induced gastric ulceration. Based on the decreased ulcer index, Alhagi maurorum induced significant antiulcerogenic effect against aspirin-induced gastric ulceration with a curative ratio of 90.3 and 85.6% respectively. The number of ulcers and total acidity were significantly (P<0.01) decreased. Improvement of the histopathological picture of liver tissue and the serum biochemical parameters (AST, ALT, GGT and Albumin) indicated that a good hepatoprotective effect against CCl4-induced hepatotoxicity was achieved by oral administration of methanol extract of Alhagi maurorum. No symptoms of discomfort were reported after doses of up to 2.5 g kg-1. Methanol extract of Alhagi maurorum was reported to contain unsaturated sterols, triterpenes, tannins, flavonoids and carbohydrates and/or glycosides as active constituents. GC-Ms analysis revealed the presence of\n\n24 compounds of which Luteolin (14.88%), Amarogentin (23.22%), Palmitic acid (24.23%), inoleic acid (6.6%) are major constituents. This study proved that the methanol extract of Alhagi maurorum has a promising gastro- and hepatoprotective effect in rats.

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