📚 Volume 29, Issue 10
📋 ID: 3ESQaF1
Authors
Hans Thompson, Erik Ito, Lei Wilson
, Erik Ito, Lei Wilson
Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Keywords
bis-chloroacetamide
sulfide compounds
antimicrobial activity
antioxidant activity
chloroacetylation
4-aminobenzohydrazide
sulfur reagents
Abstract
4-Aminobenzohydrazide (1) undergoes twice chloroacetylation at both primary amine and hydrazide-NH2 functions. The conforming bis-chloroacetamide derivative 3 that produced was reacted with different sulfur reagents (namely; 2-mercaptobenzothiazole, 6-amino-2-mercaptopyrimidin-4-ol, and 2-mercapto-4,6-dimethyl-nicotinonitrile) to give new bis-sulfide compounds 5, 7 and 9, respectively. The newly synthesized bis-chloroacetamide and their corresponding sulfides were screened for antimicrobial and antioxidant potential. The sulfide derivative 7 exhibited the most potent activity against Staphylococcus aureus and Pseudomonas aeruginosa with inhibition activities 83.3% and 78.3%, respectively. Moreover, the sulfide derivative 7 showed the highest antioxidant activity with an inhibition ratio = 85.9%, which comes very close to L-ascorbic acid.
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📝 How to Cite
Hans Thompson, Erik Ito, Lei Wilson , Erik Ito, Lei Wilson (2022).
"Utilization of bis-chloroacetamide derivative in the synthesis of new biologically active sulfide compounds".
Wulfenia, 29(10).
