ABSTRACTBackground: Degeneration can precede herniation of the IVD that is followed by local radix inflammation and pain. The purpose of this study is to investigate the total antioxidant status, and total oxidant status, their ratio, and the oxidative stress index in patients who have cervical disc herniations. Methods: Between June 2017 and July 2020, 48 patients, in whom cervical disc disease was detected via radiological examination, and 49 healthy subjects participated in the study. TAS, TOS, paraoxonase, lipid hydroperoxydase levels were measured through the use of commercially available kits. OSI levels were calculated based on their ratio.Results: Forty-eight patients, 25 female (52.1%) and 23 male (47.9%), were selected for the study, with a mean age of 41.4 � 5.96 years. No difference was identified between the patient and control groups with respect to either age and gender (p>0.005). The patients� lipid hydroperoxydase, TAS, and paraoxonase levels were significantly lower than those seen in patients in the control group (p<0.001). TOS levels and OSI were significantly higher in the patient group (p<0.001). Conclusions: Increased oxidative stress may be associated with pain and neurological deficits in patients, who have cervical disc herniation, and long-term follow-up studies are needed on this subject.Keywords: Spinal herniation; Antioxidant free radical; Oxidative stress

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