Introduction: Skin conditions contributed 1.79% to the global burden of 306 diseases and injuries in 2013. It was found that the normal human skin microbiome had high diversity and high interpersonal variation. The microbiota compositions of diseased lesional skin (in atopic dermatitis and psoriasis) showed distinct differences compared to healthy skin. The role of microbial colonization in establishing immune system homeostasis has been reported, while host-microbe interactions and genetically determined variation of stratum corneum properties may be linked to skin dysbiosis. Objective: To analyze through a systematic review the main considerations about the intestinal Skin-Microbiota axis, presenting the importance of intestinal health for healthy skin. Methods: The model followed for the systematic review was PRISMA. The search strategy was performed in the PubMed, Embase, Ovid and Cochrane Library, Web Of Science, Science Direct Journals (Elsevier), Scopus (Elsevier), OneFile (Gale) databases. Results: For the development and understanding of the regulatory processes involving the intestinal Skin-Microbiota axis, chronic inflammation is a crucial factor for the development of autoimmune diseases. Specifically, pathological T cells residing in the skin of psoriasis patients produce excess IL-17 in response to IL-23, triggering the production of pro-inflammatory mediators IL-1?, IL-6, IL-8, TNF-?, and keratinocyte chemoattractants. These signaling molecules support chronic skin inflammation and cause epidermal hyperplasia. The interaction of hormonal, neuronal, and inflammatory signaling has a major impact on skin health. Psychological distress alters the physiology of the skin, stimulating proinflammatory responses. Also, psychological stress positively regulates prolactin secretion, which in turn determines keratinocyte proliferation and sebum production by the sebaceous glands. Similarly, the appearance of autoimmune skin diseases such as psoriasis and allergic disorders such as atopic dermatitis is correlated with chronic inflammation and degranulation of mast cells. Conclusion: Current scientific evidence reveals the existence of an important intestinal Skin-Microbiota axis, highlighting the management of dermatoses through probiotics and prebiotics, as well as a lifestyle change. Managing skin diseases in the future may include manipulating bowel function. Treatments that increase or repair a leaky barrier bowel may become important as adjunctive therapy in the management of inflammatory skin diseases and may help increase the effectiveness of standard dermal therapy. All of this would be aimed at modifying the secretory, metabolic and hormonal activity of the intestinal epithelium to impact skin inflammation.

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