📚 Volume 28, Issue 3
📋 ID: V4SCqqJ
Authors
Luiz Sergio Milanez Ronchi, Otavio Augusto Fonseca Veiga, Maria Fernanda Ribeiro Cury, Ana Laura Carvalho Achkar, Carolina Garcia Francisco, Gabriela de Marco Cuginotti, Luiz Gabriel Milanez Ronchi, Rafael de Oliveira Guena, Thalyta Aparecida Leite de Lima, Myka Paloma Antunes Ferreira Mascarenhas, Geraldo Magela de Faria Junior, Durval Ribas Filho, Idiberto Jose Zotarelli Filho, Patricia da Silva Fucuta, Patricia Maluf Cury, Tamara Veiga Faria
FACERES
Abstract
Introduction: In the context of diabetes mellitus (DM) and the occurrence of skin wounds, herbal medicine with Morinda citrifolia linn, known by the name Noni fruit, is a fruit native to the Pacific Islands, Polynesia, Asia, and Australia that can traditionally be used for cancer treatment, diabetes, anti-inflammatory, wound healing among others. Objective: To analyze the therapeutic effect of Morinda C.L. on wound healing in diabetic Wistar rats, in addition to analyzing its potential benefits as an oral hypoglycemic in type I diabetes mellitus. Materials and methods: A total of 14 rats were used, which passed by the chemical induction of Diabetes Mellitus, being necessary to wait 3 days after administration of the inducing substance for the development of diabetes. For chemical induction of diabetes, the animals were kept on a solid fast for 24 hours. After this period, the weighing and dosing of the glycemia of each individual in the pre-induction were performed. Glucose levels were monitored using a commercial OneTouch Ultra glucometer. The joint analysis of the effects of epithelialization time and the control group of the numerical variable (wound area) was performed by Analysis of Variance (ANOVA), and Tukey\'s post-test. The histological evaluation variables were analyzed using the Mann Whitney non-parametric test, with p <0.05 (CI95%). Results: Noni has a hypoglycemic action in animals with type I diabetes. There was a statistical difference in the mean of blood glucose values (p <0.001). Also, Noni can accelerate the wound healing process in diabetic animals despite having a hypoglycemic action. The wound area of animals using Noni was statistically greater than the area of wounds of animals in the control group, p <0.001. The animals in the Noni group (considering all subgroups) had a lower liquid intake (34 mL/day) than the animals in the control group (72 mL/day) (p = 0.002). The animals in the Noni group (considering all subgroups) had a higher average weight (314 mg) than the control group (210 mg, p = 0.004). Conclusion: There was faster healing of wounds in diabetic animals when compared to controls, as well as the Noni group showed a hypoglycemic action.
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Luiz Sergio Milanez Ronchi, Otavio Augusto Fonseca Veiga, Maria Fernanda Ribeiro Cury, Ana Laura Carvalho Achkar, Carolina Garcia Francisco, Gabriela de Marco Cuginotti, Luiz Gabriel Milanez Ronchi, Rafael de Oliveira Guena, Thalyta Aparecida Leite de Lima, Myka Paloma Antunes Ferreira Mascarenhas, Geraldo Magela de Faria Junior, Durval Ribas Filho, Idiberto Jose Zotarelli Filho, Patricia da Silva Fucuta, Patricia Maluf Cury, Tamara Veiga Faria (2021).
"THERAPEUTIC EFFECT OF MORINDA CITRIFILIA LINN ON WOUND HEALING IN DIABETIC WISTAR RATS".
Wulfenia, 28(3).