This work was designed to evaluate the renoprotective effect of curcumin(Cur) or curcumin nanoparticles (CurNps) in chronic renal failure induced by adenine (AD) in male rats. Thirty-six adult male rats were divided into six groups, 6 rats each. The control, AD group, rats fed chew diet containing AD at a dosage of 0.25% w/w for 5 weeks, Cur orally gavage (100mg/kg b.wt.), CurNps orally received at a dose of 100mg/kg b.wt., the fifth and sixth groups were giving Cur or CurNps pre-administration of a diet containing AD by the same dose and route as groups 3, 4&2 respectively. The results showed that serum creatinine (SCr), blood urea nitrogen (BUN), uric acid (UA), urine microprotien& urine volume were significantly increased in AD fed group. Besides, we noticed a decline in antioxidant tested parameters accompanied by excessive MDA concentration, percentages of Bax, caspase-3, TNF-α, I-6& TGFβ, while percentages of Bcl2&VEGF; were significantly declined. Conversely, oxidative stress and renal function abnormalities caused by AD were potentially protected by the use of Cur or CurNps where most of these parameters go toward the normal value especially with the use of CurNps.

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