AbstractThe purpose of the study was to compare the effectiveness, safety and pregnancy outcomes of misoprostol (PGE1) to dinoprostone (PGE2) in the induction of term pregnancies. A retrospective observational study was conducted on two research group, the first induced with PGE1 and another with PGE2. The medical documentation of the Hospital for Gynecology and Obstetrics, Clinical-Hospital Centre Zvezdara was used. There was a total of 171 pregnant women hospitalized for elective or planned labor induction. PGE1 and PGE2 were administered vaginally (50 ?g PGE1, 3mg PGE2), with a cardiotocography repeated every two hours. If there was a need, inductions were continued at the maximum daily dose of 150 ?g PGE1 and 6 mg PGE2. The induction of term pregnancies with PGE1 was almost equally effective and safe as the induction with PGE2 if the clinical protocol was adequately followed. Apgar score at 5 minutes after birth was statistically higher in the group of PGE1 induced pregnant women compared to PGE2 induced. Further high-quality studies assessing the possible effectiveness of PGE1 and PGE2 in selected groups of patients are a priority in order to reduce complications in both pregnant women and infants.Keywords: misoprostol, dinoprostol, PGE1, PGE2, induction of labor, Apgar score

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