Aims: We examined the inhibitory effect of Kurozu moromimatsu (Kurozu-M) for vascular endothelial growth factor (VEGF) in the liver tissue to clarify the mechanisms of anti-carcinogenic effect of Kurozu-M in hepatocellular carcinoma (HCC) model.\nMethods: Sixteen F344 rats were divided into the two groups; control group that received basal rodent diet and Kurozu-M group that received basal diet including 2% Kurozu-M. Murine model of HCC was induced by administration of diethylnitrosamine (DEN) and weight changes were examined in both groups. All rats were sacrificed at 18 weeks after initial administration of DEN and serological tests, histology and VEGF levels of the liver were compared between both groups.\nResults: Body weights in Kurozu-M group at 18 weeks were significantly higher than those in the control group. Although there were no differences of serum levels of transaminases, albumin, and total bilirubin and histological findings of the liver, VEGF level (pg/mL) in the liver tissue was significantly lower in Kurozu-M group (192.1 ± 26.4) than that in the control group (290.4 ± 32.5).\nConclusion: Inhibitory effect for hepatic expressions of VEGF was estimated as one of the anti-carcinogenic mechanisms of Kurozu-M in DEN-induced HCC model.

Login to Download PDF

Please login with your Paper ID and password to access the full PDF.

🔑 Login to Download