📚 Volume 27, Issue 6 📋 ID: hnLs6vT

Authors

Sahar H.ElHini, AmiraTaha Zaki, Eglal MSHamed, Yehia Z Mahmoud, Amel Mahmoud Kamal eldin, Hend M. Abdelghany

Sahar H. El Hini Professor of Endocrinology and Diabetes, Diabetes and Endocrinology unit, Department of Internal Medicine, Faculty of Medicine, El Minia Univeristy, Egypt.

Abstract

Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from insulin resistance and/or impaired insulin secretion. Prediabetes is an intermediate state of hyperglycemia with glycemic parameters above normal but below the diabetes threshold. Single nucleotide polymorphism (SNP) studies in the promoter region of tumor necrosis factor alpha (TNF? (238G/A)) have suggested its role in increased insulin resistance and also in the progression from prediabetes to type 2 diabetes (T2DM). Transcription factor 7 like 2 (TCF7L2) gene has been found to be one of the most risky genes for prediabetes and progression toT2DM. But, the underlying mechanism of this is still unknown.
This is a review article demonstrated the possible mechanisms of both TNF? G/A 238 rs361525 and TCF7L2 C/T rs7903146: gene polymorphisms in prediabetes and Type 2Diabetes Mellitus.
Key words: Type2 Diabetes, prediabetes, genes, insulin resistance, TNF? G/A 238, TCF7L2 C/T gene polymorphisms.
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📝 How to Cite

Sahar H.ElHini, AmiraTaha Zaki, Eglal MSHamed, Yehia Z Mahmoud, Amel Mahmoud Kamal eldin, Hend M. Abdelghany (2020). "The Pivotal role of both TNF? 238G/A and TCF7L2 C/T gene polymorphisms in Type 2 Diabetes". Wulfenia, 27(6).