Concomitant systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) is an uncommon clinical scenario and the precise mechanisms of this phenomenon have remained unclear. Some drugs for IBD may lead to drug-induced lupus (DIL), although the prevalence of this condition is not high and it usually resolves after the discontinuation of the offending drug. This report reviews the English and Japanese literature covering the reported concomitant cases of (idiopathic) SLE and IBD. Thirty-four cases of concomitant idiopathic SLE and IBD (stratified as 19 cases with concomitant Crohn’s disease and 15 cases with concomitant ulcerative colitis) were identified. Among the 34 cases of concomitant idiopathic SLE and IBD, 79.4% (27/34) were female. In total, 61.8% (21/34) of patients were diagnosed with SLE before IBD, 29.4% (10/34) of patients were diagnosed with IBD before SLE, and 8.8% (3/34) received simultaneously diagnoses of IBD and SLE. The first disease was almost never active at the time of diagnosis of the second disease. The outcomes of concomitant cases of SLE and IBD were relatively favorable.

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