Purpose: \nTo evaluate the effectiveness and safety and long term benefit in treatment with autologous platelet-rich plasma(PRP) in patients with osteoarthritis of the knee joint and evaluation of analgesia intake.\nMethods: \nThe authors performed a retrospective study included 98 revaluated adult patients with osteoarthritis of the knee joint (128 knees), which were treated by multiple intra articular IA PRP from 2009-2012. The clinical outcome was measured after 6-9 years using the WOMAC, PGIC and NRS. On examination, the authors evaluated the pain killer usage.\nResults: \nAll 128 knees were treated with multiple IA injections and followed up for 6-9 years. The average index value For NSR and WOMAC before and after application of PRP was significant during improvement time. The PGIC values measured after the PRP application was significant over 81% in more than one year. The usage of oral analgesia was regular in (7%), and without analgesics in up to 70% \nConclusions: \nAutologous PRP as an effective, simple, relatively low cost, minimally invasive and safe method in treatment of early stages of knee osteoarthritis in long term. No patient had transmission of infectious diseases or allergic reactions after PRP treatment. Intra-articular injections of PRP significantly decreases pain and restore function.

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