The use of statins is well established in the literature for its hypolipidemic action, having beneficial effects in the treatment of cardiovascular diseases. In addition to the use of dyslipidemia, a literature has pointed to the occurrence of bone anabolic effects where mesenchymal cells differentiate in osteoblasts through BMP-2 secretion. The objective of this systematic review was to answer a clinical question formulated in PICO format: Simvastatin influences bone remodeling? A Pubmed / MEDLINE search was conducted for articles published up to May 2019, which considered various factors such as dosage, area, recorder, area and effects of use. Of the 20 articles that fit the inclusion and exclusion criteria, 18 (90%) had positive results in bone remodeling, 50% of articles published in the last 5 years and 100% of articles on animals.\nMuch of the evidence about the role of topical simvastatin in bone regeneration comes from animal studies (especially rats) focusing on extraoral bone defects. Still, preliminary results are encouraging and it is suggested that use with a suitable vehicle may aid in the process of bone repair and osteoinduction.

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