Purpose: Mechanism of bevacizumab induced hypertension is not clear. In our study we aimed to evaluate the possible predictive role of carotid artery intima media thickness (CIMT), brachial artery flow-mediated dilation (FMD), metabolic syndrome parameters, proteinuria and also determine the frequency of hypertension by 24-hour blood pressure monitoring. \nMaterials and methods: Metastatic colorectal cancer patients who administered combine chemotherapy regimens with bevacizumab, were included in study population. We measured blood pressures by 24-hour blood pressure monitorization, carotid artery intima media thickness, brachial artery flow mediated dilation ratios and 24 hour urine protein levels of study population before and after third cycle of chemotherapy.\nResults: Sixteen patients were included in study population. There was statistically significant difference between 120.second FMD measurements before and after third cycle of chemotherapy (p=0.04). Statistically important correlation was detected between 60.second FMD measurements and systolic blood pressure levels after third cycle of chemotherapy which was the indicator of endothelial dysfunction (p=0.02, r=-0.69).\nConclusion: Until now no study has been reported which has evaluated the effects of bevacizumab on endothelium by using FMD measurements. This is the first study to treat this theme. Further studies with large patient numbers will be more informative.

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