This study was applied to investigate the hepatoprotective activity of ethanolic extracts of edible Rhamnus (Ziziphus spina Christil L.) Mulberry (Morus alba L.) and sage (Salvia officinalis) alone and against carbon tetrachloride (CCl4) induced hepatic damage in rats. Oral administration of CCl4 (1 ml/kg body wt. /day.S/C) induced a chronic hepatotoxicity resulting elevated serum level of glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT) and alkaline phosphatase (ALP). The substanially elevated serum marker enzyme levels were restored towards normalization by the extract treatment when administered at a dose of 500 mg/kg body wt. once daily. The hepatic antioxidant status such as catalase (CAT), glutathione peroxidase (GPX), glutathion S. transferase (GST) and total antioxidant activity (TAC) levels are reduced in CCl4 alone treated animals with subsequent increase in malondaldhyde lipid peroxidase (MDA). Administration of the extracts challenge restored the hepatic antioxidant status. Furthermore, histopathological studies confirmed the hepatoprotective effect. The findings suggested that ethanolic extracts of Z. spina and M. alba exhibited a moderate liver protection while S. officinalis exhibited a high liver protection against CCl4 induced chronic hepatotoxicity in rats by restoring the liver antioxidant status.\nKeywords: Ziziphus spina Christi, Morus alba, Salvia officinalis, Carbon tetrachloride, Hepatoprotective effect, Rhamnus, Mulberry, Sage.\nIntroduction

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