Cigarette smoke closely related with chronic obstructive pulmonary disease (COPD). Cigarettes contain 1015-1017 free radicals and more than 4700 chemicals, that can cause inflammation in the lungs. This study aims to look at the protective effect of ethanolic extract of P. ostreatus on cigarette smoke-induced lung toxicity in rat.\n This experimental used 24 rats divided into: Group I (normal), group II (negative control), Group III (treatment-ethanolic extract of P. ostreatus 250 mg/KgBB rat/day) and Group IV (comparison-NAC 600 mg/day). Group II, III and IV was given 1 hour/day/group of cigarette smoke exposure. The lung toxicity will be seen from the histopathological and hemolytic profile.\n Histopathological injury analyzed using Annova and showed significant results (p≤0,01) and post-hock test with bonferoni (p≤0,01) showed that the ethanolic extract of P. ostreatus was significantly different from negative control. The results of examination of leukocytes, lymphocytes, hemoglobin and hematocrit, showed no significant results (p= 0.14) with the Fisher extract test.\n The conclusion shows that the ethanolic extract of P. ostreatus can prevent lung toxicity in on cigarette smoke-induced Lung Toxicity in rat. Ethanolic extract of P. ostreatus has good antioxidant potential.

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