Purpose: Mechanism of bevacizumab induced hypertension is not clear. In our study we aimed to evaluate the possible predictive role of carotid artery intima media thickness (CIMT), brachial artery flow-mediated dilation (FMD), metabolic syndrome parameters, proteinuria and also determine the frequency of hypertension by 24-hour blood pressure monitoring. \nMaterials and methods: Metastatic colorectal cancer patients who administered combine chemotherapy regimens with bevacizumab, were included in study population. We measured blood pressures by 24-hour blood pressure monitorization, carotid artery intima media thickness, brachial artery flow mediated dilation ratios and 24 hour urine protein levels of study population before and after third cycle of chemotherapy.\nResults: Sixteen patients were included in study population. There was statistically significant difference between 120.second FMD measurements before and after third cycle of chemotherapy (p=0.04). Statistically important correlation was detected between 60.second FMD measurements and systolic blood pressure levels after third cycle of chemotherapy which was the indicator of endothelial dysfunction (p=0.02, r=-0.69).\nConclusion: Until now no study has been reported which has evaluated the effects of bevacizumab on endothelium by using FMD measurements. This is the first study to treat this theme. Further studies with large patient numbers will be more informative.
In this paper we have established recurrence relations for single and product moments\nof generalized order statistics from Kumaraswamy-log-logistic distribution. Further\nthe results are deduced for moments of record values and order statistics.
Introduction: In the scenario of retinography (RG) studies due to the incidence of diseases in the fundus of the eye, diabetic retinopathy (RD) stands out with about 34.6%, accounting for 4.8% of the 37 million cases of blindness around the world. In addition, GR is also indicated for the analysis of age-related macular degeneration, glaucoma, peripheral degeneration, toxoplasmosis scarring, retinal vascular occlusions, and other lesions. Objective: To compare the \"Daytona®\" device with the conventional indirect ophthalmoscopy (CIO) method, mainly analyzing the diagnosis and the location of the lesions. Methods: A total of 45 participants were analyzed by means of a prospective longitudinal study, following a comparative model, as shown below, following the rules of Consort. Each patient performed both Daytona® and standard indirect ophthalmoscopy examinations, mainly analyzing the diagnosis and location of the lesions. The present study was approved by the Research Ethics Committee under the number: 1.678.583. A common descriptive statistical analysis was performed with mean, standard deviation and percentage values. Anderson-Darling normality test was applied in all predictors. It was followed by Linear Regression Analysis due to the presence of continuous predictors in relation to the predictor\'s responses, with p <0.05 as being statistically different, with 95.0% CI. Multivariate analysis (Dendogram) was also applied. Results: The results obtained in the present study revealed that Daytona® (DAY) was able to identify 31.1% of the diagnoses of 45 patients diagnosed with the CIO. Despite this, DAY was able to identify other types of lesions and also in other locations in the retina (as a horizontal meridian) in relation to Indirect Ophthalmoscopy. Conclusion: The Daytona® wide-angle retinograph is a great tool for documentation and screening of retinal diseases in patients without pupillary dilatation. However, it has a low ability to identify peripheral lesions, especially in the superior and inferior meridians.
Keywords: Enfamama, favorite, milk, SPSS.
We characterize a program that can improve the occupational safety and health (OSH) of precarious workers, a group that includes individuals employed in lower skilled workers in microenterprises, self-employed individuals without special skills or certifications, unskilled individuals with non-standard employment, and temporarily unemployed individuals. Five years ago, we began a small project that supported the health of workers in small-scale workplaces as a joint activity of a local NGO medical organization and a support center for non-standard workers, with support from a large labor union in a district of Ulsan (South Korea). Over time, we developed relationships with additional public resources, such as a regional Workers Health Center and a local public health center, and developed a cooperative system among these parties. The interventions intended to improve the health status of workers at small-scale factories initially consisted of health checkups and health counseling. After 5 years, so this program now provides more comprehensive OHS interventions that target many precarious workers. \nThese activities in Ulsan highlight that the OSH of precarious workers cannot be addressed with the existing OSH system, and that the participation of community health care providers is necessary. Thus, there should be a new paradigm for improving the health of precarious workers, in which there is a shift of focus from the ‘workplace’ to the ‘worker’, because the current workplace-focused OSH approach cannot cover precarious workers. The health of precarious workers can be more appropriately managed using a worker-focused approach, in which there is networking of occupational and community health resources. Our experience in Ulsan inspired us to develop a new paradigm — a worker-focused approach — which may also be effective in other cities or countries.
Evaluation becomes an indispensable element for the teaching-learning process, since it allows to measure teaching methods and techniques. The objective of this research was to identify the type of learning strategies and how students apply them in their study methods. This was done through an instrument that allowed identifying the evaluation scenarios and identifying the types of evaluations. As a result, it was found that a meaningful percentage of students memorize the concepts and very few remember the theory after an examination or evaluation. Therefore, this paper also intends to formulate a proposal to exemplify strategies for the promotion of meaningful learning.
In this paper, we study the local dynamics and bifurcations analysis of a two-dimensional discrete-time host-parasitoid model in the closed first quadrant R_+^2. We study the local dynamics along their topological types about equilibria: O(0,0),A(1,0) and B(l,r(1-l)) of the discrete-time model by utilizing method of Linearization. We also investigate necessary and sufficient parametric condition(s) under which the unique positive equilibrium B(l,r(1-l)) of the discrete-time model is locally asymptotically stable, repeller, saddle and non-hyperbolic. It is proved that about boundary equilibrium A(1,0) discrete-time model undergoes a period-doubling bifurcation. It is also proved that discrete-time model undergoes a Neimark-Sacker bifurcation when parameter varies in a small neighborhood of the unique positive equilibrium point B(l,r(1-l)) and meanwhile stable invariant close curve appears. From the viewpoint of biology, the stable closed curve corresponds to the periodic or quasi-periodic oscillations between host and parasitoid populations. Some numerical simulations are presented to verify theoretical results.
Dengue fever is considered as one of the serious illness and a major\ninternational health concern. Over the years Dengue fever has emerged\nin Jazan region, Saudi Arabia.This paper deals with susceptible, infective and recover model from mathematical epidemiology to describe\nthe spread of dengue based on the hospitalized dengue cases in Jazan region.The threshold value Rt which is similar to reproduction number of the model signies the stability analysis of disease free and endemic equilibrium points. We show the necessary and sufficient condition for\nendemic equilibrium point to be locally stable. The dynamic behavior\nwith respect to the changes of the parameters and stability of the equilibrium points are discussed. Also, we present the interval that includes\nheteroclinic orbit for the model.
Background: In the dental implant scenario, the graft to treat severely reabsorbed jaws is currently the gold standard procedure, but there are flaws in this procedure from 10.0 to 30.0 % are reported in the literature. Zygomatic implants have shown, in many cases, improved clinical outcomes compared to bone graft and represent an essential alternative for compromised maxillary bone. Objective: Therefore, the present study analyzed the main literary findings on the use of the zygomatic implant as a necessary alternative for a dental implant. Methods: Experimental and clinical studies were included (case reports, retrospective, prospective, randomized trials and systematic review and meta-analysis) with qualitative and/or quantitative analysis, following the rules of systematic review- PRISMA. Significant findings and Conclusion: The zygomatic implant is revolutionizing the procedure of implants in the posterior atrophic maxilla, eliminating the complications of bone augmentation and elevation of the sinus, with delayed cicatrization. Zygomatic implants have in many cases shown better clinical results compared to bone graft and represent a possible gold standard for a dental implant.