Acute abdomen is an important issue for physicians to timely intervention. The early diagnosis and treatment can significantly improve the mobility and mortality. The etiology of acute abdominal sign was reported in previous studies, such as abdominal aortic dissection, abdominal aortic aneurysm rupture, and hollow organ perforation. The typical symptoms were severe abdominal pain, cold sweating, and cannot be improved by pain killer. In some atypical patients, the acute abdominal sign is difficult for physician to find. Here, we present a case of a 69-year-old male who presented with acute onset progressive abdominal cramping pain, fever and chills, cough and dysuria. The physical examination revealed hypoactive bowel sound, periumbilical tenderness, and coarse breath sound. The multiple infection was suspected: pneumonia, urinary tract infection, and intra-abdminal infection. Computed tomography of abdomen revealed local fat stranding and suspected acute sigmoid diverticulitis. After surgical intervention, the abnormal colon tissue with mild local infection and perforation was found. The pathology report showed sigmoid adenocarcinoma. He discharged and followed up at outpatient department. This paper describes the clinical and image features of hollow organ perforation and highlights the early diagnosis and timely treatment for avoiding a potentially devastating outcome.
Components assignment problem to maximize the network reliability in the case of each component has an assignment cost and lead-time is never discussed. Therefore, this paper focuses on solving this problem under an assignment cost and total lead-time constraints. The presented problem is called an optimal components assignment problem (OCAP) and it is based on three constraints namely total assignment cost, total lead-time, and system reliability. Also, an approach based on random weighted genetic algorithm (RWGA) is presented to solve the OCAP. The results revealed that an optimal components assignment leads to the maximum reliability, minimum assignment budget and minimum total lead-time using the proposed approach.
Nine Escherichia coli shiga-toxin producing (STEC), human enteropathogenic (EPEC) isolates were subjected to RAPD-PCR using three universal primers; primers 4, 5, and 6, to study their heterogeneity. Primer 6 was the most successful in developing heterobands for most of the investigated isolates and resulted in six clades. Primer 6 highly discriminated three of the most virulent isolates; isolates 7, 8, and 5. Primer 4 ranked the second successful primer, fortunately it placed the fourth most virulent isolate, isolate 6, into a separate clade with a high linkage distance of 3.9 separating it from the rest of the isolates. None of the investigated primers developed heterobands for the isolates 1, 2, and 3 which were always treated as one with zero Euclidean linkage distance among them. Primer 6 RAPD-PCR patterns for isolates 7, 8, and 5 as well as primer 4 RAPD-PCR pattern for isolate 6 could be regarded as reference patterns for the direct detection of such isolates and other related ones especially in Al-Kharj district. Additionally, heterobands of the most virulent isolates, in further investigations, could be studied to be used as markers for the detection of virulent EPEC, STEC isolates.
Due to the highly development of semiconductor, the efficiency of brushless DC motor (BLDC) has more high efficiency with its rivals and the cheap cost. Thus, it has been widely applied to farm, lawn and garden machinery as well as home appliance However, the BLDC motor drive is a highly nonlinear multivariable and time-varying system, the conventional proportional integral derivative (PID) control with fixed parameters is difficult to reach satisfactory performance. The neural networks have been applied to motor drive design in recent years because it has a fast learning ability and self-adjustment property. In order to obtain fast dynamic control response of a motor drive, a radial basis function neural network (RBFNN) based PID control of motor drive is proposed in this manuscript. By using the RBF neural network, the mathematical model of the motor drive can be identified so that the PID gain parameters can be properly tuned according system variations in real time. Finally, the PID controller using RBF neural network to adjust the gain parameters is designed and realized in this manuscript. The experimental results verified the feasibility and fidelity of proposed RBFNN-based PID controller performance.
Our research goal is to carry out the analysis ofdiversity of the FTO gene and the relation of gene variants with obesity at Yakuts with type 2 diabetes mellitus. 132 DNA samples from patients with the diagnosis of diabetes mellitus type 2 were tested (women - 91, men - 41). In the cohort of a healthy comparison group, there was created a sampling of 22 men and 48 women. Distribution analysis of allelic and genotypes frequencies of polymorphic variant of the FTO gene (rs9939609) in the group of patients with type 2 diabetes mellitus and the healthy comparison group did not diagnosticate significant differences. In both groups prevailed the T allele (р=0.252) and the TT homozygous genotype (р=0.820); an exception was the group of apparently healthy men which, in despite of the T allele prevalence (р=0.08), was characterized by the highest level of AT heterozygous genotype (Ho=0.546). It was found that a marker of the higher risk of obesity development of Yakut patients with type 2 diabetes mellitus on ethnic origin are the TT homozygous genotype of FTO gene (rs9939609).
The aim of the study was to investigate the vitamin D level in normotensive and hypertensive patients with diabetes mellitus type 2 (T2DM) with/without cardiovascular disease (CVD). Cross-sectional data of 155 patients with T2DM were analyzed. Sixty-seven patients had CVD (aged 63.6±1.0yrs, BMI 29.2±0.5kg/m2). Eighty-eight diabetic patients did not have the history of CVD (aged 61.0±0.9yrs, BMI 29.9±0.4kg/m2). We compared these two groups of patients with T2DM with 87 healthy subjects (35 male/52 female, aged 52.8±1.4yrs, BMI 27.2±0.5kg/m2). Weight, height, waist circumference, body mass index (BMI), blood pressure and history of antihypertensive drugs were recorded in all subjects. Total cholesterol, triglycerides, HbA1c and 25(OH)D levels were measured in all subjects. According to 25(OH)D level, we divided all subjects into three categories: severe vitamin D deficiency (≤15ng/ml), vitamin D insufficiency (15-20ng/ml) and vitamin D sufficiency (˃20ng/ml). Normotensive and hypertensive patients with T2DM without CVD were vitamin D sufficient in comparison with healthy subjects (21.8±1.2ng/ml and 21.6±1.1ng/ml vs. 22.6±0.8ng/ml,p˃0.05). Hypertensive patients with T2DM with CVD (n=49) were vitamin D insufficient in comparison with healthy subjects (19.4±0.9ng/ml vs. 22.6±0.8ng/ml; p=0.017; Z-2.397). This cross-sectional study showed that there were no differences in vitamin D levels between normotensive and hypertensive patients with T2DM.
The present study aimed to investigate the different responses of sensitive and tolerant \nrice genotypes under water stress condition induced using poly ethylene glycol (PEG \n6000). The studied genotypes were Giza177, Giza181, Giza182 and Sakha103 \n(sensitive), Sakha104 (moderate), Orabi2 and N38 (tolerant). The present \ninvestigation included determination of germination %, fresh and dry weight, shoot \nand root length, cell membranes stability as rate of electrolyte leakage (EL), lipid \nperoxidation as MDA content. Semi-quantitative reverse transcriptase polymerase \nchain reaction (sqRT-PCR) for some protective proteins such as heat stable proteins \n(HSPs) and Dehydrins (DHNs) standardized on actin transcript amounts were carried \nout to investigate the changes in the expression pattern of those genes. All \ndeterminations were carried out for all studied genotypes under both control and \ndrought conditions. The obtained results revealed that water stress tolerance of \ntolerant genotypes was accompanied with decreasing of electrolyte leakage rate and \nlow content of MDA comparing with sensitive ones. sqRT-PCR analysis for \nexpression pattern of studied genes showed increasing in the expression of HSP-13, \nHSP-12, HSP-9 and DHN-2 in the seedling of tolerant genotypes comparing with \nsensitive ones. The present study pointed to the participation of those genes in the \nacquisition of drought tolerance in tolerant genotypes.
The fruit peel serves as a barrier to counteract the attack of pathogenic organisms. Additionally to the physical defense exerted by peel, a diversity of chemicals compound is synthesized in this tissue that serves to inhibit the proliferation of the pathogenic organisms. The polyphenols take part of this chemical mechanism. In this regard, it has been widely demonstrated that some polyphenols (e.g. resveratrol) exert toxic properties toward cells. Thereby, the aim of this work was to investigate the toxic properties of polyphenols extracted from the peel of Punica granatum (pomegranate). First, we extracted the active compounds from pomegranate peel using four different solvents. Then, to determinate total phenols, we used Folin-Ciocalteau method, and we found that when we used 80% methanol plus 20% water (solvent A) as a solvent, we extracted the higher amount of polyphenols (26.46 mg EAG/100 mg DE from the batch I and 14.18 EAG/100mg DE from batch II). Furthermore, we calculated total flavonoids using aluminum chloride, and we obtained with solvent A the higher concentration of flavonoids (35.30 µg EQ/100 mg DE from batch I and 26.99 µg EQ/100 mg DE from batch II). Besides, the higher antioxidant potential with ABTS+ and DPPH+ were obtained from extracts with 80% ethanol plus 20% acetone (solvent D) and solvent A, respectively. Finally, to corroborate the biological activity of our extracts we made antibiotic activity assays using Kirby-Bahuer method, for this purpose we used the microorganisms Escherichia coli and Staphylococcus aureus, in which we observed inhibition halos ranged from 1.5 and 2.0 cm with concentrated extracts, and with dry extracts ranged from 0.2 and 0.7 cm, respectively. Altogether, this data corroborates that the extracts from the pomegranate peel serve to inhibit the proliferation of bacterial cells.
The aim of this study was to investigate the process of identity formation among incarcerated adolescent offenders and the influence of context in this process, based on significant elements from their life stories, as narrated by the subjects themselves. The study design was cross-sectional and qualitative. Interviews were conducted with representative teenagers using the life story method, and network analysis was then employed to determine the patterns of semantic connections in the discourse. Among the main results, it was found that the experience of adolescent offenders, particularly within the family environment, created regulatory opportunities in the process of identity formation; adolescents experienced the infraction as a means of acquiring consumer goods and gaining respect and social recognition, negating the emancipatory possibilities; incarceration was shown to be a reinforcing structure, preserving the status quo; and, finally, the life project tended to favour the maintenance of heteronomy. It is concluded that identity formation among incarcerated adolescent offenders was shown to be a process for regulatory possibilities, hindering the development of autonomous capacity in search of human emancipation. This process of identity formation offers fertile ground for immersion in the world of crime and criminal recidivism.\n\nKey-words: Violence; identity issues; risk behaviors; delinquency; crime; incarceration.
