Bone marrow derived MSCs (BM-MSCs) and adipose derived MSCs (AD-MSCs) are among the types of stem cells most commonly studied. Our study aims to compare the therapeutic efficacy of allograft AD-MSCs versus BM-MSCs in a mouse model of hindlimb ischemia. AD-MSCs were isolated from belly fat and BM-MSCs were isolated from femur bone marrow. They were used to treat mice with acute hindlimb ischemia. Treatment efficacy was compared among 4 groups: injected with BM-MSCs, injected with AD-MSCs, non-treated and injected with phosphate buffered saline. Mice in the groups were evaluated for the following: necrosis grade of leg, leg edema, blood flow, muscle cell restructure and new blood vessel formation. Results showed that AD-MSC transplantation significantly recovered acute limb ischemia, with 76.5% of mice fully recovered, while the ratio was only 48.5% in BM-MSC transplanted group, and 0% in the non-treated and PBS groups. Evaluation of leg edema, blood flow, muscle cell restructure and new blood vessel formation also supported the observation that AD-MSC transplantation was superior over BM-MSC transplantation. Therefore, AD-MSCs may serve as the more suitable MSC for hindlimb ischemia treatment and angiogenesis therapy.
The objective of this study is to determine proportions of lengths and widths of all phalanges and metatarsals in relation to big toe distal phalanx length and width and finding possible relations between all metatarsals themselves, phalanges themselves and both metatarsals and phalanges. This study was conducted on 110 X-rays (Both right and left sides) that taken from 110 volunteers (55 men and 55 women).Lengths and widths proportions of all metatarsals and phalanges to big toe distal phalanx length and width in both men and women were measured on X-rays. The relations between metatarsals and phalanges regarding their lengths and widths were studied using spss to analyze data. The mean, standard deviations, minimum and maximum proportions of all metatarsals and all phalanges’ lengths and widths in relation to length and width of big toe distal phalanx were recorded. This study found that there is a fixed relation between metatarsals with each other, between phalanges with each other and between metatarsals and phalanges in terms of their lengths and widths. These relations may be helpful in orthopedic or cosmetic surgery to manage congenital anomalies of the foot.
ABSTRACT\nThe knowledge of the atmospheric scenario constitutes one of the basis of the environmental analysis. Any statement regarding air or water quality can be exposed to serious errors if it is not based on a precise determination of the atmospheric scenario. This is even more important in a region with such a complicated terrain as the Mediterranean side of the Iberian Mountain Range, where the Coal Thermal Plant of ENDESA in Andorra (Teruel) started operating in 1979-1980. The large scientific confrontation developed since then shows that the main conclusions did not answer key questions due to an insufficient knowledge of the atmospheric media. The Mixing Height constitutes, together with the volume of emissions, an important parameter in the modeling of the dispersion and impact of the atmospheric pollutants. This is the objective of this research work, whose difficulty is increased by the stand-alone character of the Mediterranean meteorological scenario.\nKeywords: Atmospheric Boundary Layer (ABL), Mixing Height, atmospheric diffusion, turbulence and stability of the ABL.
Objective: The aim is to demonstrate the changes in functional magnetic resonance imaging (FMRI) of the brain in a patient with pigmentary retinal dystrophy of both eyes, which is the most often discussed topic in relation to the bionic eye.\nPatient and methods of examination: The authors report the case of a 63-year-old patient with pigmentary retinal dystrophy of both eyes. The patient underwent a complete eye examination, including visual functions, photographs and functional magnetic resonance imaging. (FMRI).\nResults: Visual acuity of the right and left eye was 0.2 and 0.3 respectively. Visual field of the right and left eye – concentric narrowing to 10 and 5 degrees respectively. Despite the above visual functions, the visual centre of the brain did not show any activity on FMRI. \nConclusion: Our work demonstrates that damage to the retinal cells is also associated with damage of the visual cortex in the brain. This also explains the relative failure of \"bionic eyes\".
Purpose: Galectins play an important role in autoimmune/inflammatory and malignant diseases. However, the precise role of galectin 1 (Gal-1) and galectin 3 (Gal-3) in pathogenesis of ulcerative colitis (UC) is still unknown. \nMethods: We examined the expression of Gal-1, Gal-3, TNF-α, TGF-β, IL-10 and IL-4 in UC patients and healthy controls by enzyme-linked immunosorbent assay (ELISA) and flow cytometry.\nResults: We found that serum concentration of Gal-1 was significantly increased in the UC patients with mild inflammation of the colon tissue when compared with UC patients with severe inflammation. Moreover, we found a strong significant positive correlation between Gal-3 and TNF-α. In vitro, LPS/ConA stimulated peripheral blood mononuclear cells (PBMNCs) obtained from UC patients produced significantly higher amounts of Gal-3 and TNF-α, but less TGF-β and IL-10. There was significantly higher percentage of CD14+Gal-3+ macrophages in peripheral blood cells of UC patients than in healthy controls.\nConclusion: In conclusion, our results indicate the importance of Gal-3 and pro-inflammatory cytokine TNF-α in pathogenesis of UC and also systemic Gal-1 seems to have protective effect on inflamed tissue in UC patients. \nKey words: Galectin-1, Galectin-3, ulcerative colitis
The concept of water footprint can be applied to business companies to provide indications about the sustainability of their production process and the global impact on water resources.\nThe objective of this study is the water footprint accounting of an hypothetical pasta factory making a comparison between an international and an Italian pasta production.\nWhen the pasta factory takes its raw materials from France, Australia and Italy, it uses 1847 m3 of water per each ton of pasta, while assuming an Italian origin about durum wheat cultivation, the business water footprint rises to 2360 m3/ton.\nThese results depend on the production site, local environment conditions and agricultural techniques used to cultivate durum wheat needed to produce wheat semolina and then dry pasta.\nAlthough Italy is one of the most productive country in this food sector, it is clear that an hypothetical italian pasta factory could create a major impact on water resources trough processing national wheat than foreign one.
The present investigation was conducted to compare bile and serum concentrations of doxycycline (DOX) in turkeys after single intramuscular (IM) and oral administrations of 20 mg/kg body weight (b.w.). Furthermore, the entero-hepatic circulation and absolute bioavailability from gastrointestinal tract of DOX after oral dose were accessed. Three groups of male turkeys of five each received DOX at a dose rate of 20 mg/kg b.w. intravenously, intramuscularly and orally. Samples of serum and bile excreted were taken at predetermined intervals during 6 h. DOX concentrations of were determined by a reverse phase high-performance liquid chromatography (HPLC) with UV detection at 347 nm. After intravenous (IV) injection the elimination half-life (T1/2), the total body clearance (Cltot) and the volume of distribution (Vss) were 3.90 h, 0.55 L/h/kg and 2.39 L/kg, respectively. The maximal serum concentrations (Cmax) of DOX in turkeys were 4.38 and 3.17 µg/ml, with time to peak concentration (Tmax) values of 0.74 and 1.00 h and absolute bioavailability were 71.83 % and 48.81 %, after IM and oral administrations respectively. The bile concentrations were up to 100 times higher than those in serum. The cumulative biliary excretion of the administered dose DOX was about 7% and 3% recovered from the bile within the first 6 hr after IM and oral dosing, respectively. After oral dose the entero-hepatic circulation model is based on the classical one compartment model with bile elimination half-life (T1/2k1g) of 5.36 h and the maximal bile concentrations (Cmax) was 222.39 µg/ml. Therefore DOX could be relevant for treatment of cholecyctitis and enteric infectious diseases.
A study was undertaken to examine the influence of synthetized zinc oxide nanoparticles (ZnO NPs) on different parameters of seed germination, seedling growth, and antioxidant system response of S. lycopersicum. The seeds were treated with different concentrations (0, 5, 10, 15 and 20 mgL-1) of ZnO NPs obtained by the molten salt method, and compared with the same dosages of commercial bulk ZnO. According to the results, the 5 mg L-1 dose promoted a better germination (93 %), greater root and shoot length (13.35 cm and 3.25 cm, respectively), as well as a better seed vigor index, which was increased threefold (1546.28 ± 100.30) compared to the control (509.60 ± 51.10). ZnO NPs showed a differential enzyme activity and enhanced the antioxidant system depending on the concentration evaluated. Our findings indicate that ZnO NPs promoted seed germination of S. lycopersicum by enhancing the antioxidative defense system, which finally resulted in increased seedling growth.
This article will try to define migration as one of the central topics that concern Balkan countries in the entire 20th century. We will try to classify it, and follow the history of “traditional” migrations in the Balkans. We will analyze migration in the context of significant social processes in the 20th century such as wars between Balkan countries, inequalities in the standard of living between particular countries and globalization.
The effect of extract from Korean wine waste on the production of cytokines by murine splenocytes was investigated using concanavalin A (Con A) as a stimulant. The culture supernatants of splenocytes exposed to 85% aqueous methanol (MeOH) fraction along with Con A were harvested to determine the production of cytokines [interleukin (IL)-2, IL-4, IL-5, IL-6, IL-12/IL-23(p40), and interferon (IFN)-γ]. Cytokines were measured using ELISA. Co-administration of 85% aq. MeOH fraction (3 μg/mL) and Con A significantly reduced IL-2 expression at 6 h, as compared to treatment with only Con A (p<0.05). Co-administration of 85% aq. MeOH fraction and Con A significantly increased IL-4 (at 3 μg/mL) and IFN-γ (at 10 μg/mL) expression at 24 h, as compared to treatment and only Con A (p<0.05). These results indicated that the 85% aq. MeOH fraction from Korean wine waste decreased the expression of proinflammatory cytokine, IL-2 and increased the expression of anti-inflammatory cytokines, IL-4 and IFN-γ, suggesting that the anti-inflammatory effect of the 85% aq. MeOH fraction may be associated with the higher levels of phenolic compounds, oleic acid, and n-3 polyunsaturated fatty acids (PUFA).
Location based services in indoor environments has been recently addressed as an important issue. Global Navigation Satellite System is not suitable for indoor LBS because of multipath effects and distortion of the Global Positioning System. Various techniques using wireless radio signal have applied for indoor positioning such as Wireless Local Area Network, Bluetooth, Ultra-wideband and so on. However, these techniques cannot be used freely because they require additional infrastructure. In this paper, an indoor positioning scheme exploiting inertial measurement unit, map matching and particle filter (PF) is proposed and the performance of the proposed scheme is evaluated with conventional schemes. In the proposed scheme, dynamic step distance estimation and gyroscope sensor based heading estimation are employed to improve traveled distance and heading estimation accuracy. To reduce the accumulated error problem of IMU, the position correction scheme exploiting map information and the PF is applied to improve accuracy of position estimation. The performance of proposed scheme is evaluated with different number of particles through the developed application in indoor environments and is compared with those of conventional schemes. According to the experiment results, the error of step distance estimation is decreased from 19% to 6.4% compared to the fixed step distance. The error of position estimation of proposed scheme is also decreased from 18% to 3% compared to those of conventional schemes.
Purpose: This study was aimed to investigate whether the aldehyde dehydrogenase activator (Alda-1®) reduces neuronal damage in a rat model of binge ethanol exposure.\nMethods: Thirty-six adolescent male rats (130-150 g) were randomly assigned into three groups; sham, ethanol-only group (25% ethanol intragastrically thrice daily for four days, approximately 10 g/kg/day) and ethanol with Alda-1® group (10 mg/kg thrice daily for four days). The ALDH activity of baseline and 90 min after last infusion of each group was measured. Brain damages were investigated by using Luxol fast blue-Cresyl violet stain in the hippocampus, CA1 and CA2/3. The activation of astrocytes and microglia were examined using immunohistochemistry for antiglial fibrillary acidic protein (GFAP) and anti-ionized calcium-binding adapter molecule 1 (Iba-1).\nResults: After four day binge, the ALDH activity level was doubled in ethanol with alda-1® group (mean: 7.87, SD: 0.67), whereas, the levels of sham group (mean: 4.07, SD: 0.53) and ethanol only group (mean: 3.77, SD: 0.36) were slightly decreased. The more significant neuronal shrinkage, fewer neurons, loss of Nissl substance of the hippocampus were observed in the ethanol only group in comparison to the ethanol with Alda-1® group. The astrocytosis and microgliosis of the hippocampus were also more activated in the ethanol only group than those in the ethanol with Alda-1® group.\nConclusion: The administration of Alda-1® reduces the cytotoxic damage of the hippocampus in adolescent rats with binge ethanol exposure.
There has been a steady increase in the utilisation of mobile devices recently, due to technology advancements attained in the area of mobile communications and the integrated features of mobile units. Insider threat has always been a problematic issue faced by organisations and with a large majority of users now equipped with mobile devices, it has now become an even more prominent issue. Freedom of movement and ubiquitous accessibility to information makes it necessary for a solution to be available to address such potential threats. In this paper, a unique profiling method is introduced using carefully selected database objects as well as data concerning the location of the database requests, in order to produce a comprehensive intrusion detection framework which is sensitive to the locations where database requests are initiated from. The conduct of experiments implementing the system has resulted in promising detection rates achieved, with low rates of false alarms observed.
Existing classifications of temperament, characters, personality types and ways of behaviour are the\ndisputable issues of the present-day scientific world. The origins of the classifications rise from the\nancient philosophy and medicine in China and India (VIII BCE), Greece (V BCE), Rome (II\ncentury AD), England and Germany (ХIХ century), USA and Russia (ХХ century). Tremendous\namount of the classifications were worked out all over the world and not all of them withstood the\ntest of time. The references to Hippocrates‟ and Claudius Galenus‟ classifications occur chiefly,\nwhich are tangential with regard to mentality and psychic setup and based on humoralism\n(humorism). Great empirical and experimental materials have been accumulated in scientific history\nwithout harmonious systematization in view of the absence of the integrated international system of\nclassification that is the factor restraining the further development of typology. There were curious\nincidents during typology march. Fourier described three hundred characters, for instance.\nUnfortunately, any ordinary person could not be able to remember all these descriptions. Since then,\nresearches, finding and admission of the optimum types became the task of paramount importance\nfor the scientists.
Detection of five genes, slt-I, slt-II, eaeA, rfbE, and fliCh7, involved in shiga toxin production was investigated in nine E. coli local isolates using multiplex PCR. Three annealing temperatures were investigated where 53C was the temperature resulting in the best annealing of the shiga toxin primers in the nine E. coli isolates. A statistical dendrogram was conducted to illustrate the developed gene profiles of the isolates. Slt-II was detected in all E. coli isolates while intimin was the least detected being found in only three isolates; 7, 6, and 8. Multiplex PCR could be used as a valuable diagnostic tool for the detection of shiga toxin-producing E. coli isolates. Also, the current results spot the light on the possible use of multiplex PCR as a virulence measure.
Frequency reconfigurable antennas have many benefits that can be used to improve the performance of wireless systems. This work presents a new design of a frequency reconfigurable SIW hexagonal cavity-backed antenna. The proposed antenna is printed on a dielectric substrate and fed by a grounded coplanar waveguide GCPW attached to a 50 ohm microstrip line, the radiation is obtained by a graved U-slot in the ground plane of the structure. To control and tune the antenna resonance frequency, two BBY31 Varactor diode are used, they are able to switch the operating frequencies considerably, without much affecting the radiation characteristics and gain. Simulated results, that are obtained by Ansoft HFSS software, shows that the frequency ratio varying from 10.75 to 10.4 with different aspect ratios
This paper provides an overview of researches covering development of the National Spatial Data Infrastructure (NSDI) in Western Balkan country - Serbia. Analysis of the existing studies about NSDI in Western Balkan countries clearly shows that in all countries there are ongoing initiatives on NSDI implementation in the line with INfrastructure for SPatial InfoRmation in Europe (INSPIRE) Directive. The NSDI stakeholders cover public administration organs, local government organs, public enterprises, legal persons entrusted with geo data management, legal persons using data and services within the NSDI. The present paper elaborates cooperation level achieved among the NSDI stakeholders, in the areas of operation: existing cooperation in geo data exchange, product users, pricing policy, product pricing model, financing model, role of the national geo portal, geo data sharing/distribution and e-payment.
Periurethral abscess is a life-threatening infection of the male urethra and periurethral tissues. The standard treatment consists of immediate suprapubic urinary drainage and wide debridement. Owing to the further improvement of antibiotics and surgical technique, alternative treamtment method might be considered.\n This report is to present a rare case with periurethral abscess. A 62 year-old male suffered from fever, chillness, dysuria, scrotum uncomfortable, frequency, and urgency for weeks. The following CT showed the lesion of periuretral abscess.\n The suprapubic tube cystostomy combined with transurethral endoscopic incision were done smoothly. After 7 days of antibiotics treatment, he discharged from our hospital and there was no recurrent for more than two years.\n We present a case of periurethral abscess, which was treated with transurethral endoscopic incision successfully. In a review of the published literatures, antibiotics using was necessary and open debridement was suggested to prevent this life-threatening infection. Debridement need more time and cost to treat it and always made patient uncomfortable. By using transurethral endoscopic drainage, treatment of periurethral abscess is much easier and made patient more satisfactory about the result.
Foreign bodies in the human lower genitourinary tract is rare. We present an 56 years-old male voided out one budding and one dark-brown colored stone at the same time on September 19, 2015. It was the first case of urethral plant been reported in human.
Human uterine leiomyosarcoma (LMS) is neoplastic malignancy that typically arises in tissues of mesenchymal origin. The identification of novel molecular mechanism leading to human uterine LMS formation and the establishment of new therapies has been hampered by several critical points. We earlier reported that mice with a homozygous deficiency for proteasome beta subunit 9 (PSMB9)/b1i, an interferon (IFN)-g inducible factor, spontaneously develop uterine LMS. The use of research findings of the experiment with mouse model has been successful in increasing our knowledge and understanding of how alterations, in relevant oncogenic, tumour suppressive, and signaling pathways directly impact sarcomagenesis. The IFN-g pathway is important for control of tumour growth and invasion and has been implicated in several malignant tumours. In this study, experiments with human tissues revealed a defective PSMB9/b1i expression in human uterine LMS that was traced to the IFN-g pathway and the specific effect of somatic mutations of Janus kinase (JAK1) molecule or promoter region on the PSMB9/b1i gene transcriptional activation. In addition, Comparative genomic hybridization (CGH) analyses showed that human uterine LMS having a clear functional loss at JAK1 (1p31-p32) and PSMB9/b1i (6p21.3) also harbored one nonsense mutation and one deletion, suggesting a possible homozygous loss of function. Understanding the molecular mechanisms of human uterine LMS may lead to identification of new diagnostic candidates or therapeutic targets in human uterine LMS.
To evaluate the antioxidative activity of Euphorbia supina extract, we examined its effect on genomic DNA oxidation and glutathione (GSH) production of in HT-1080 cells. Its ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azinobis(3-ethylbenothiazoline-6-sulfonic acid) ABTS) radicals was also measured. Both acetone+methylene chloride (A+M) and methanol (MeOH) extracts, and the 85% aqueous MeOH fraction significantly inhibited oxidative DNA damage (p<0.05). GSH levels were significantly increased by both A+M and MeOH extracts (p<0.05). Among fractions, the treatment of cells with the 85% aqueous MeOH fraction significantly increased GSH levels at concentrations of 0.5 mg/mL (p<0.05). In DPPH and ABTS radical scavenging assays, both A+M and MeOH extracts and the 85% aqueous MeOH and n-BuOH fractions showed marked scavenging activity at low concentrations compared with butylated hydroxytoluene (BHT). The 85% aqueous MeOH fraction showed the highest antioxidative effect and may contain valuable active compounds. It may be concluded that extracts and fractions from E. supina have the nutraceutical value as potent antioxidants by scavenging free radicals and alleviating the radical-induced damage.
This study successfully used the molecular dynamics to understand new polymer carbon nanotube materials composited by the acyl chloride (Cl) functional groups of multi-wall carbon nanotube (MWNT) and epoxy resin. The nanotensile test simulation was used to understand the composition of the nanocomposite strengthening phenomenon, and to explore the strengthening mechanism also. It was found that the functional groups of carbon nanotubes and polymer materials construct the higher Young\'s modulus. The constitute interface (binding force) of the nanocomposite polymer carbon nanotube composites was larger than pure carbon nanotubes and polymer materials. And, it can be found that increasing the number of MWNT, the Young\'s modulus of nanocomposite also increased. Formation of the chemical bonding between the functionalized carbon nanotubes and polymers can indeed provide a higher strength than the physical combination.
Agave (Agave tequilana Weber var. azul), it is commonly known as “Agave tequilana or Agave Tequilero”. The Agave crop is a product economically important of Mexico because it is the fundamental ingredient for tequila, whose economic income by the quantity that is exported represents an important currency generator. Looking for improve new technologies in the crop of Agave tequilero. The objective of this research was to monitor the process of induction and development of embryogenic callus in plantlets of A. tequilana subjected to ionizing radiation in vitro plantlets of Agave tequilana Weber cultivar blue irradiated with Co60 gamma rays. Plantlets were irradiated with Co60 Gamma Rays 0 (control), 10, 20 and 30 Gy. The embryogenic callus were induced from plantlets irradiated using Murashige and Skoog medium (MS) supplemented with 2,4-D, BA and Kinetin. Significant differences were obtained in the behavior of radiation treatments on competent cells (bipolar) during induction, obtaining 60% induction of embryogenic callus after 14 days of incubation at independent radiation dose. The development of induction indices of embryogenic callus decreased during the incubation period with 10 and 20 Gy dose of radiation. The higher growth of the callus was presented in the lapse of 21 to 28 days of incubation In 30 Gy dose callus induction was inhibited. The callus diameter and callus weight are positively correlated.
ABSTRACT:\n Purpose: The present investigation was carried out to evaluate the possible antioxidant effects of Syzygium aromaticum (clove) and Salvia officinalis (sage) extracts for modulating the oxidative stress which might be caused by monosodium glutamate (MSG) in testis tissues of rats.\n Methods: 49 male rats were divided into 7 groups (n = 7): the 1st (control group); 2nd (MSG – treated group); 3rd (clove – treated group); 4th (sage – treated group); 5th (MSG + clove – treated group); 6th (MSG + sage – treated group) and 7th (MSG + clove and sage mixture – treated group).\nAfter 30 days, the animals were sacrificed, blood samples were collected and serum samples were harvested for determination of testosterone hormone levels. The tissues of the right testes were prepared to determine the levels of malondialdehyde (MDA), nitric oxide (NO) and glutathione (GSH) and the activity of superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GPx) and glutathion reductase (GR). While, the left testes were used for collecting semen which was immediately used for the assessment of sperm count, morphology and motility.\n Results: MSG – treated group showed significant increase in MDA and NO levels, while showed significant decrease in the level of GSH and in the activity of SOD, CAT, GPx and GR enzymes as compared with control group. The clove – treated group and sage – treated group did not show any significant changes in the former parameters as compared with control group. Whereas the groups of MSG plus clove, sage or their mixture showed significant decrease in MDA and NO levels, while showed significant increase in the level of GSH and in the activity of SOD, CAT, GPx and GR enzymes as compared with MSG – treated group. \nMSG – treated group showed significant decrease in sperm concentration, morphology and motility. The clove – treated group and sage – treated group did not show, in general, any significant changes in sperm concentration, morphology and motility as compared with control group. Whereas the groups of MSG plus clove, sage or their mixture showed significant increase in sperm concentration, morphology and motility as compared with MSG – treated group. \nMSG – treated group showed significant decrease in the levels of serum testosterone. The clove – treated group and sage – treated group did not show any significant changes in serum testosterone levels as compared with control group. Whereas the groups of MSG plus clove, sage or their mixture showed significant increase in serum testosterone levels as compared with MSG treated group.\n Conclusion: Clove and sage extracts have a vital protective role and may be suggested as a good and safe candidate for mitigating the oxidative stress induced by MSG on testis tissues which in turn, would serve as a promising indicator for the health effects of clove and sage on male fertility.
The 0.9Pb(Zr0.49Ti0.51)O3 – 0.07Pb(Mn1/3Nb2/3)O3 – 0.03Pb(Sb1/2Nb1/2)O3 + x wt% ZnO ceramics, where x = 0.05 ? 0.5, has been prepared by two-stage calcinations method. The effect of the ZnO addition on the sintering behavior and dielectric properties of ceramic samples have been investigated. It showed that the ZnO addition significantly improved the sinterability of the ceramics, resulting in a reduction of sintering temperature from 12000C to 9500C. All samples have pure perovskite phase, the phase structure of ceramics changes from rhombohedral to tetragonal with the increase of the ZnO content. Analysis of the microstructure evolution showed that the solubility limit of Zn ions in PZT – PMnN – PSbN systems was about 0.25 wt%. At the ZnO content of 0.25 %wt, dielectric properties of ceramics are best: the density of 7.82 g/cm3, the the dielectric constant, ?r = 1555, ?max = 29090, the dielectric loss (tan?) of 0.006. A highest value of ?max ? 20000 was found at 1 kHz with the temperature Tm of around 575K. Using an extended Curie-Weiss law the diffuse phase transition was determined. Cole- Cole analyses showed the non - Debye type relaxation in the system studied.